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Position of Cyclization in Cyclic ADP-Ribose

Authors
Publisher
Elsevier Inc.
Publication Date
Volume
194
Issue
3
Identifiers
DOI: 10.1006/bbrc.1993.1941
Disciplines
  • Physics

Abstract

Abstract Cyclic adenosine diphosphoribose (cADPR) is a putative second messenger of calcium homeostasis synthesized from NAD by cleavage of the nicotinamide-ribose bond and cyclization of the ribose to the adenine ring. In this study, the ultraviolet absorption spectra of cADPR have been studied as a function of pH and compared to other compounds containing an adenine ring with substitutions at known positions. The results support a structure for cADPR in which cyclization is to position 1 of the adenine ring, rather than to N 6 , as has been previously proposed.

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