Abstract Rapid prenatal diagnosis of common aneuploidies (21, 18, 13 trisomy and sex chromosome) can be performed by the Quantitative Fluorescence Polymerase Chain Reaction (QF-PCR) of Short Tandem Repeat (STR). The main advantages of the QF-PCR are its rapidity (24–48 h), accuracy and automation. Furthermore, its provides an additional and useful contribution for the karyotype analysis. Recently, three kits are commercially available for the in vitro diagnosis of common chromosome aneuploidies by QF-PCR. In this study we have evaluated two of these kits: Chromoquant Version 2 and Aneufast.