Affordable Access

Publisher Website

Biological Insights into Therapeutic Protein Modifications throughout Trafficking and Their Biopharmaceutical Applications

Authors
Journal
International Journal of Cell Biology
1687-8876
Publisher
Hindawi Publishing Corporation
Publication Date
Volume
2013
Identifiers
DOI: 10.1155/2013/273086
Keywords
  • Review Article
Disciplines
  • Biology
  • Engineering
  • Medicine
  • Pharmacology

Abstract

Over the lifespan of therapeutic proteins, from the point of biosynthesis to the complete clearance from tested subjects, they undergo various biological modifications. Therapeutic influences and molecular mechanisms of these modifications have been well appreciated for some while remained less understood for many. This paper has classified these modifications into multiple categories, according to their processing locations and enzymatic involvement during the trafficking events. It also focuses on the underlying mechanisms and structural-functional relationship between modifications and therapeutic properties. In addition, recent advances in protein engineering, cell line engineering, and process engineering, by exploring these complex cellular processes, are discussed and summarized, for improving functional characteristics and attributes of protein-based biopharmaceutical products.

There are no comments yet on this publication. Be the first to share your thoughts.