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Comparison of local neurotoxicity of three white spirit formulations by percutaneous exposure of rat tail nerve

Authors
Journal
Toxicology Letters
0378-4274
Publisher
Elsevier
Publication Date
Volume
21
Issue
3
Identifiers
DOI: 10.1016/0378-4274(84)90086-9
Keywords
  • White Spirit
  • N-Nonane
  • Neuropathy
  • Trimethylbenzene
  • Dimethylbenzoic Acid
  • Percutaneous Exposure
Disciplines
  • Biology

Abstract

Abstract A recently developed technique was used to compare the local neurotoxicity of three white spirit (crude oil distillates) formulations. They differed in aliphatic and aromatic hydrocarbon concentrations. Formulations I and II contained over 10% n-nonane, whereas its concentration was negligible in formulation III with 17% aromatics. Formulation I contained no aromatics. Formulation I and II caused local axonopathy by neurophysiological and morphological criteria after 6 weeks of daily 3-h exposures for 5 days a week. No neurophysiological changes were caused by formulation III while morphological analysis revealed infrequent demyelinative foci after 6 weeks. Rats exposed to formulation II with 1% trimethylbenzene isomers showed urinary excretion of dimethylbenzoic acid isomers not detected in other rats thus providing a method for the biological monitoring of exposure.

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