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Dopamine and depression: A review of recent evidence. II. Theoretical approaches

Authors
Journal
Brain Research Reviews
0165-0173
Publisher
Elsevier
Publication Date
Volume
6
Issue
3
Identifiers
DOI: 10.1016/0165-0173(83)90006-1
Keywords
  • Dopamine
  • Depression
  • Animal Models
  • Learned Helplessness
  • Reward
  • Responsiveness

Abstract

Abstract This paper discusses 3 behavioural approaches to depression, ‘learned helplessness’, reward system dysfunction and reduced responsiveness to the environment, and the role of dopamine (DA) in their related animal models. The meso-limbic and nigrostriatal DA system appears to be related primarily to responsiveness to the environment. This conclusion is discussed in relation to the clinical symptomatology of depression.

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