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SIRT1 Regulation—It Ain't All NAD

Authors
Publisher
Elsevier Inc.
Publication Date
Volume
45
Issue
1
Identifiers
DOI: 10.1016/j.molcel.2011.12.017

Abstract

SIRT1 is a phylogenetically conserved energy sensor. The molecular mechanisms that regulate its catalytic activity, however, are incompletely understood. Gerhart-Hines et al. (2011) have identified β-adrenergic/cAMP signaling as a regulatory input that rapidly controls SIRT1 activity and fatty acid oxidation.

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