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Do Non-Genomically Encoded Fusion Transcripts Cause Recurrent Chromosomal Translocations?

Authors
Publisher
Molecular Diversity Preservation International
Publication Date
Keywords
  • Recurrent Chromosomal Translocations
  • Leukemia
  • Solid Tumors
  • Genetic Rearrangements
  • Rna-Templated Dna Repair
  • Premature Transcript Termination
Disciplines
  • Biology

Abstract

(3) splicing to a transcript of another gene (intergenic trans-splicing), leading to “non-genomically encoded fusion transcripts” (NGEFTs). These NGEFTs bear the potential risk to influence DNA repair processes, since they share identical nucleotides with their DNA of origin, and thus, could be used as “guidance RNA” for DNA repair processes. Here, we present experimental data about four other genes. Three of them are associated with hemato-malignancies (ETV6, NUP98 and RUNX1), while one is associated with solid tumors (EWSR1). Our results demonstrate that all genes investigated so far (MLL, AF4, AF9, ENL, ELL, ETV6, NUP98, RUNX1 and EWSR1) display ETTs and produce transpliced mRNA species, indicating that this is a genuine property of translocating genes.

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