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Investigating micronutrients and epigenetic mechanisms in relation to inflammatory bowel disease

Authors
Journal
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
0027-5107
Publisher
Elsevier
Publication Date
Volume
690
Identifiers
DOI: 10.1016/j.mrfmmm.2010.02.006
Keywords
  • Chromatin Immunoprecipitation
  • Dna Methylation
  • Folic Acid
  • Inflammatory Bowel Diseases
  • Nutrigenomics
  • Selenium
Disciplines
  • Biology
  • Medicine

Abstract

Abstract Epigenomic regulation, via DNA methylation, histone modification and non-coding RNA, is increasingly recognised as having a key role in normal development and function of an organism, acting to control cellular and tissue growth and differentiation. It is also thought to be involved in many complex diseases now common in the Western world, including cardiovascular disease, type 2 diabetes, obesity and inflammatory bowel disease (IBD). There is a range of evidence to suggest that nutrition plays a vital role in the protection from such diseases. However, there is little information about the role of nutrition on the epigenetic regulation of IBD. This review aims to elucidate the interactions of nutrients and the epigenome in IBD. More specifically, the plasticity of epigenetic modifications that occur due to low selenium and folate levels in the diet during gestation and lactation will be discussed. A better understanding of this plasticity, and of nutrient–epigenome interactions, will have important implications for enhancing human health through foods.

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