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Deoxyhalogeno Sugars

Elsevier Science & Technology
DOI: 10.1016/s0065-2318(08)60384-4
  • Biology
  • Chemistry
  • Medicine
  • Pharmacology


Publisher Summary This chapter reviews that for several years, there has been considerable interest in deoxyhalogeno sugars, not only because of their potential intrinsic value in biochemistry and pharmacology, but also because of their utility in the synthesis of other rare sugars, such as deoxy and aminodeoxy sugars. The chapter discusses that the search for new methods of synthesis of halogenated carbohydrates continues to be an active area of investigation in several laboratories. A further stimulus has been provided by the discovery that halogenations of the carbohydrate moieties of some antibiotic substances afford products having activities superior to those of the parent compounds and having improved chemotherapeutic properties. This chapter collates new information on the synthesis and chemistry of deoxyhalogeno sugars other than glycosyl halides and deoxyfluoro sugars, and discusses the mechanistic and conformational aspects of some selected methods and reactions considered to be of utility.

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