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Optimization of temperature programming in gas chromatography with respect to separation time. I. Temperature programme optimization fundamentals

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  • Computer Science


PII: S0021-9673(00)94694-6 Journal of Chromatography, 370 (1986) 219-234 Elsevier Science Publishers B.V., Amsterdam - Printed in The Netherlands CHROM. 18 994 OPTIMIZATION OF TEMPERATURE PROGRAMMING MATOGRAPHY WITH RESPECT TO SEPARATION TIME IN GAS CHRO- I. TEMPERATURE PROGRAMME OPTIMIZATION FUNDAMENTALS V. BARTo* and S. WICAR Institute of Analytical Chemistry. Czechoslovak Aca&my of Sciences, Leninova 82, CS-611 42 Brno (Czechoslovakia) and G.-J. SCHERPENZEEL and P. A. LECLERCQ Department of Chemical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven (The Netherlands) (Received May 27th, 1986) SUMMARY The ranges of separability of neighbouring component pairs in a given mixture, separated isothermally on a given chromatographic column, are defined. These ranges are calculated by approximation functions fitted to the measured values of the retention times and peak widths during isothermal analyses. The sequence of the most difficult to separate component pairs is determined within the temperature sep- arability ranges of the component pairs of the mixture. This sequence determines the strategy for calculation of the optimum temperature programme, and every step of this sequence determines the substrategy. The purpose of the strategy is to find the optimum temperature trajectory (programme) and the purpose of the substrategy is to find the optimum subtrajectory, i.e., a part of the optimum trajectory. The deter- mination of the strategy and the corresponding substrategies is presented for mixtures of components that do not change their mutual position during isothermal separa- tions within the whole temperature range. INTRODUCTION Temperature programming in gas chromatography (GC) has been studied since this technique was used for the separation of mixtures with widely different boiling points of the individual components. Various workers have dealt with this problem from different viewpoints. Harris and Habg

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