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Arachidonic acid and nitric oxide production by glutamate receptors in cultured neurons

Authors
Journal
Seminars in Neuroscience
1044-5765
Publisher
Elsevier
Publication Date
Volume
5
Issue
3
Identifiers
DOI: 10.1016/s1044-5765(05)80051-x
Keywords
  • Arachidonic Acid
  • Glutamate Receptors
  • Na+/Ca2+Exchanger
  • Nitric Oxide
  • No-Synthase
Disciplines
  • Biology
  • Pharmacology

Abstract

Metabotropic glutamate (Glu) receptors via G proteins and ionotropic Glu receptors via an increase in intracellular Ca 2+, trigger synthesis of intra- and intercellular messengers. In this chapter, we review the pharmacological characteristics and the mechanisms by which identified ionotropic and metabotropic Glu receptors alone, or in association, stimulate the synthesis of two putative retrograde messengers, arachidonic acid (AA) and nitric oxide (NO), in cultured neurons.

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