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Characterization of PEGylated nanoliposomes co-remotely loaded with topotecan and vincristine: relating structure and pharmacokinetics to therapeutic efficacy

Authors
Publisher
Elsevier BV
Publication Date
Keywords
  • Recently
  • Developing Drug Delivery Systems Exhibiting Controlled Drug Release At The Tumor Sites Emerged As An
  • It Seems
  • However
  • Unlikely That Single Agent Therapies Will Prove Effective Enough Against The Myriad Cells Present Wi
  • Therefore
  • Next Generation Nanotherapeutics Must Not Only Find Their Way To The Solid Tumor But Also Must Effec
  • Nanoliposomes Offer An Important Advantage In The Delivery Of A Combination Of Drugs Acting Synergis
  • They Allow Controlling The Pharmacokinetics And Biodistribution Of The Drugs By Uniform Time And Spa
  • However
  • Successful Translation Of Such Complex Formulations Into The Clinic Relies On Understanding Critical
  • These Include: Liposomes’ Membrane Phase And Dynamics
  • Size Distribution
  • State Of Encapsulated Drug
  • Internal Environment Of Liposome
  • State Of Grafted Polyethylene Glycol At The Liposome Surface
  • And In-Vivo Drug Release Rate
  • They Determine The Pharmacokinetics Of The Formulation And The Bioavailability Of The Drugs
  • We Encapsulated The Combination Of Vincristine (Vcr) And Topotecan (Tpt) In The Same Nanoliposome (L
  • Our In-Vitro And In-Vivo Characterization Of Lipovito Provides An Explanation For The Good Therapeut
  • Moreover
  • We Have Described How To Study These Critical Features For A Two-Drug In One Nanoliposome Formulatio
  • This Characterization Is An Important Step For A Rational Clinical Development And For How To Ensure
  • © 2011 Elsevier B
  • V
  • All Rights Reserved
Disciplines
  • Medicine
  • Pharmacology

Abstract

Characterization of PEGylated nanoliposomes co-remotely loaded with topotecan and vincristine: relating structure and pharmacokinetics to therapeutic efficacy - DTU Orbit (18/04/14) Characterization of PEGylated nanoliposomes co-remotely loaded with topotecan and vincristine: relating structure and pharmacokinetics to therapeutic efficacy - DTU Orbit (18/04/14) Characterization of PEGylated nanoliposomes co-remotely loaded with topotecan and vincristine: relating structure and pharmacokinetics to therapeutic efficacy Zucker, D., Andriyanov, A. V., Steiner, A., Raviv, U. & Barenholz, Y. 2011 In : Journal of Controlled Release. Publication: Research - peer-review › Journal article – Annual report year: 2011

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