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The central vs. peripheral effects of clonidine on ACTH, corticosterone and glucose release

Authors
Journal
European Journal of Pharmacology
0014-2999
Publisher
Elsevier
Publication Date
Volume
111
Issue
3
Identifiers
DOI: 10.1016/0014-2999(85)90651-x
Keywords
  • Clonidine
  • Corticosterone
  • Glucose
  • Acth
  • Hypothalamic Noradrenaline Neuronal Activity

Abstract

Abstract The role of central vs. peripheral actions of clonidine was investigated in the rat following the separate and combined administration of clonidine and 2-deoxy-D-glucose (2-DG). Clonidine or 2-DG alone stimulated serum glucose and corticosterone but hypothalamic noradrenaline neuronal activity and ACTH release were stimulated by 2-DG only. The stimulation of noradrenaline neuronal activity and ACTH by 2-DG were totally blocked by clonidine. It was concluded that the increases in serum glucose and corticosterone after clonidine administration were not mediated by central effects but that α 2-adrenoceptor agonism by clonidine was responsible for inhibition of hypothalamic noradrenaline neuronal activity and pituitary ACTH release.

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