Affordable Access

Publisher Website

Degradation of activated protein kinases by ubiquitination.

Authors
Type
Published Article
Journal
Annual Review of Biochemistry
0066-4154
Publisher
Annual Reviews
Volume
78
Pages
435–475
Identifiers
DOI: 10.1146/annurev.biochem.013008.092711
Source
Hunter Lab

Abstract

Protein kinases are important regulators of intracellular signal transduction pathways and play critical roles in diverse cellular functions. Once a protein kinase is activated, its activity is subsequently downregulated through a variety of mechanisms. Accumulating evidence indicates that the activation of protein kinases commonly initiates their downregulation via the ubiquitin/proteasome pathway. Failure to regulate protein kinase activity or expression levels can cause human diseases.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments