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Intraepidermal squamous carcinoma (Bowen's disease) of the nipple

Authors
Journal
Human Pathology
0046-8177
Publisher
Elsevier
Publication Date
Volume
25
Issue
12
Identifiers
DOI: 10.1016/0046-8177(94)90100-7
Keywords
  • Bowen'S Disease
  • Nipple
  • Squamous Carcinoma In Situ
  • Breast
Disciplines
  • Chemistry
  • Medicine

Abstract

Abstract A case of Bowen's disease of the nipple clinically resembling Paget's disease is reported. This lesion was differentiated from other pagetoid lesions by negative histochemical stains for mucin and melanin, positive immunohistochemical preparation for high-molecular weight cytokeratin 66 kd (904) using adequate controls, and electron microscopic findings of squamous cell features. The therapeutic implications of such a pagetoid nipple lesion in the absence of an underlying breast carcinoma are discussed.

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