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Male antifertility compounds from Tripterygium wilfordii Hook F.

Authors
Journal
Contraception
0010-7824
Publisher
Elsevier
Publication Date
Volume
47
Issue
4
Identifiers
DOI: 10.1016/0010-7824(93)90036-7

Abstract

Abstract Extracts of the Chinese medicinal plant, Tripterygium wilfordii, cause reversible infertility in male animals. Sub-fractionation studies have now revealed that the plant extracts contain a number of compounds which are potent antifertility agents in male mammals, including the diterpenes triptolide and tripdiolide and an isomer of the latter. A triptolide,12, 13- chlorohydrin, which is a transformation product formed reversibly by interaction of triptolide with HCI, was also found to be active.

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