Affordable Access

Identification of a new co-crystal of salicylic acid and benzamide of pharmaceutical relevance

Springer verlag
Publication Date
  • F100 Chemistry
  • Medicine


Raman spectroscopy, X-ray powder diffraction/X-ray crystallography and differential scanning calorimetry have been used to study the phenomenon of co-crystal formation in stoichiometric mixtures of salicylic acid with benzamide. Raman spectroscopy was particularly useful for the characterization of the products and was used to determine the nature of the interactions in the co-crystals. It was observed that little change in the vibrational modes associated with the phenyl groups of the respective reactants took place upon co-crystal formation, but changes in intensities of the vibrational modes associated with the amide and the carboxylic acid groups were observed upon co-crystal formation. Several new vibrational bands were identified in the co-crystal which were not manifested in the physical mixture of both components and could be used as diagnostic features of co-crystal formation. © 2009 Springer-Verlag.

There are no comments yet on this publication. Be the first to share your thoughts.


Seen <100 times

More articles like this

Identification of a new co-crystal of salicylic ac...

on Analytical and bioanalytical c... May 2010

Solid-state 17O NMR of pharmaceutical compounds: s...

on The journal of physical chemis... Aug 22, 2013

Biochemical effects of some newer salicylic acid c...

on The Journal of pharmacy and ph... December 1966

[New derivatives of salicylic acid].

on Il Farmaco; edizione scientifi... 1957
More articles like this..