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Effect of tetraphenylboron on the calcium-dependent ATPase activity of sarcoplasmic reticulum

Authors
Journal
Biochemical and Biophysical Research Communications
0006-291X
Publisher
Elsevier
Publication Date
Volume
151
Issue
3
Identifiers
DOI: 10.1016/s0006-291x(88)80478-9
Disciplines
  • Biology

Abstract

The apparent effect of tetraphenylboron on the Ca 2+-dependent ATPase activity is rather complex being dependent of the physical state of the membrane. In leaky vesicles, tetraphenylboron decreases the affinity of the enzyme for Ca 2+, and high concentrations (100 μM) inhibit the enzyme. These effects are mediated by the membrane structure. In native vesicles, tetraphenylboron induces an apparent stimulation of the maximum hydrolytic activity and a decrease of the Ca 2+ gradient formed due to specific Ca 2+ releasing activity of the mentioned drug.

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