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Regioselective double disulfide formation using silylchloride-sulfoxide system

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
33
Issue
8
Identifiers
DOI: 10.1016/s0040-4039(00)91864-1
Keywords
  • Peptide
  • Disulfide Bond
  • Silylchloride-Sulfoxide
  • Conotoxin M1
  • β-Hanp

Abstract

Abstract Two intermolecular or intramolecular disulfide bonds are formed regioselectively by the combination of silylchloride-sulfoxide method with conventional oxidation method. This stepwise method for double disulfide formation is successfully applied to the syntheses of conotoxin M1 and β-human atrial natriuretic peptide.

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