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MicroRNA-125b Induces Cancer Cell Apoptosis Through Suppression of Bcl-2 Expression

Authors
Journal
Journal of Genetics and Genomics
1673-8527
Publisher
Elsevier
Volume
39
Issue
1
Identifiers
DOI: 10.1016/j.jgg.2011.12.003
Keywords
  • Mir-125B
  • Bcl-2
  • Apoptosis
  • Proliferation
Disciplines
  • Biology
  • Computer Science

Abstract

Abstract MicroRNAs (miRNAs) are small, noncoding RNAs which can often act as an oncogene or a tumor suppressor. Several miRNAs are associated with the development of hepatocellular carcinoma (HCC). We demonstrated that miR-125b significantly suppresses HCC cell proliferation and promotes apoptosis by inhibiting the gene expression of the anti-apoptotic protein, Bcl-2. Bioinformatic analysis indicated that the 3′UTR of Bcl-2 has binding sites for miR-125b. Luciferase reporter assay confirmed the ability of miR-125b to dramatically suppress Bcl-2 transcription, suggesting that Bcl-2 is a target gene for miR-125b. We concluded that miR-125b acts as a tumor suppressor in hepatic tumor development by targeting Bcl-2 and inducing cancer cell apoptosis.

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