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Formation of active 40 S ribosomal subunits in liver in the presence of aflatoxin B1

Authors
Journal
Chemico-Biological Interactions
0009-2797
Publisher
Elsevier
Publication Date
Volume
9
Issue
1
Identifiers
DOI: 10.1016/0009-2797(74)90061-1
Disciplines
  • Biology

Abstract

Abstract In the presence of aflatoxin B 1, 18 S RNA continues to be excised from a normal 45 S RNA, emerging into the cytoplasm in free newly synthesized 40 S subunits. The present results demonstrate that the particles so formed are indistinguishable from their control counterparts in composition and buoyant density as well as in their ability to be incorporated into polysomes. These findings suggest that 40 S subunits synthesized in the presence of aflatoxin B 1 represent active particles capable of initiating protein synthesis in rat liver cell.

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