Abstract Estrogen has been proved to be a carcinogenic agent responsible for the development of many, if not all, mammary cancers. The historical development and endocrinology of the concept of temporarily controlling and effectively palliating disseminated cancer of the breast by removal of the hormone sources has been briefly outlined. At present there is no clear-cut criterion useful in selecting patients for adrenalectomy. It seems apparent that any person afflicted with disseminated cancer of the breast should be considered a candidate for this form of therapy. To the results of this therapy on 389 cases reported in the literature are added eleven more cases, in nine of which marked palliation was received. Bilateral ovariectomy and adrenalectomies are worth while operations in the palliative therapy of disseminated cancer of the breast in that they have a low operative mortality rate and prolong the useful life expectancy of nearly one-half the patients.