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Localization of Mn-superoxide dismutase (Mn-SOD) in cholinergic and somatostatin-containing neurons in the rat neostriatum

Authors
Journal
Brain Research
0006-8993
Publisher
Elsevier
Publication Date
Volume
549
Issue
1
Identifiers
DOI: 10.1016/0006-8993(91)90618-6
Keywords
  • Mn-Superoxide Dismutase
  • Choline Acetyltransferase
  • Somatostatin
  • Neostriatum
  • Rat
Disciplines
  • Chemistry

Abstract

We used rabbit antisera against manganese (Mn)-superoxide dismutase for immunohistochemical studies of localization in the rat neostriatum. Immunostaining was intense in large-sized neurons and several medium-sized neurons, but it was moderate to weak in other cells. Double immunostaining with monoclonal antibody to choline acetyltransferase or somatostatin demonstrated large-sized. Mn-SOD immunoreactive neurons to be cholinergic, and some medium-sized neurons which were intensely immunoreactive for Mn-SOD to contain somatostatinergic.

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