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Effect of composition on gelation kinetics of unfilled and nanoapatite-filled poly(lactide-ethylene oxide-fumarate) hydrogels

Authors
Journal
Materials Letters
0167-577X
Publisher
Elsevier
Publication Date
Volume
61
Issue
30
Identifiers
DOI: 10.1016/j.matlet.2007.04.057
Keywords
  • Hydrogel
  • Hydroxyapatite Nanoparticles
  • Gel Point
  • Sol–Gel Transition

Abstract

Abstract Oscillatory shear rheometry at small strains was used to investigate the effects of composition (concentration of macromer, crosslinker, initiator/accelerator, and filler) on the gel point and ultimate storage modulus of poly(l-lactide- co-ethylene oxide- co-fumarate) (PLEOF) hydrogels. PLEOF in situ polymerizing hydrogels can be used as biodegradable scaffolds for cell encapsulation and tissue regeneration. The time evolution of the viscoelastic properties of the polymerizing mixture during the sol–gel transition was monitored using mechanical rheometry. According to the results, while the ultimate storage modulus linearly increased with the concentration of methylene bisacrylamide (BISAM) crosslinker, the values of the storage and loss moduli at the gel point were insensitive to the concentration of BISAM. Similar behavior was observed for PLEOF hydrogels reinforced with hydroxyapatite nanoparticles.

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