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The nature of fibrous dysplasia

Authors
Journal
Head & Face Medicine
1746-160X
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
5
Issue
1
Identifiers
DOI: 10.1186/1746-160x-5-22
Keywords
  • Review
Disciplines
  • Biology
  • Medicine

Abstract

Fibrous dysplasia has been regarded as a developmental skeletal disorder characterized by replacement of normal bone with benign cellular fibrous connective tissue. It has now become evident that fibrous dysplasia is a genetic disease caused by somatic activating mutation of the Gsα subunit of G protein-coupled receptor resulting in upregulation of cAMP. This leads to defects in differentiation of osteoblasts with subsequent production of abnormal bone in an abundant fibrous stroma. In addition there is an increased production of IL-6 by mutated stromal fibrous dysplastic cells that induce osteoclastic bone resorption.

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