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Effects of noradrenergic agonists and antagonists on growth hormone secretion under gamma-hydroxybutyrate narco-analgesia in the rat

Authors
Journal
Psychoneuroendocrinology
0306-4530
Publisher
Elsevier
Publication Date
Volume
5
Issue
2
Identifiers
DOI: 10.1016/0306-4530(80)90016-5
Keywords
  • Gamma-Hydroxybutyrate
  • Growth Hormone
  • Noradernergic Agonists
  • Noradrenergic Antagonists

Abstract

Abstract (1) The administration of gamma-hydroxybutyrate (GHB) has no effect on the hypothalamic concentration of norepinephrine (NE), dopamine (DA) and serotonin (5-HT) in the rat. (2) The injection of GHB induces a consistent growth hormone (immunoreactive GH) secretory episode, followed by basal levels for several hr. (3) During this period, the infusion of clonidine, an α-adrenergic agonist, elicits a dramatic GH increment, whereas basal levels are not modified by isoproterenol, a β-adrenergic agonist. (4) In animals pretreated with α- and β-adrenergic agonists, clonidine enhances the GH peak induced by GBH, which is clearly inhibited by isoproterenol. The effects of α- and β-adrenergic antagonists were also investigated in this study. (5) The data reported here could support the hypothesis that α-adrenergic receptors mediate the secretion of the GH-releasing hormone and that β-adrenergic receptors are involved in the release of somatostatin.

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