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Is vigor of regeneration a key factor in recovery from peripheral nerve injuries?

Authors
Journal
Experimental Neurology
0014-4886
Publisher
Elsevier
Publication Date
Volume
94
Issue
3
Identifiers
DOI: 10.1016/0014-4886(86)90257-8

Abstract

Abstract The nerve-growth-promoting effects of the tricyclic antidepressant, imipramine, were tested on the sympathetic ganglion of chickens and on the sciatic nerve of rats. A powerful neuronotrophic action was observed in vitro, but the utilization of the drug in vivo did not modify the functional recovery from a crush lesion.

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