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Palladium catalyzed diastereoselective addition of secondary alcohols to acyloxyazetidinones

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
3
Issue
11
Identifiers
DOI: 10.1016/s0960-894x(01)80962-8
Disciplines
  • Chemistry

Abstract

Abstract Palladium catalyzed addition of lactate esters or phenethyl alcohols to acyloxyazetidinones gives 4-oxy-substituted β-lactams with 6-9:1 diastereoselectivity. The stereochemistry of the major products was established as S*S* by X-ray crystallography.

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