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Quantitative structure-activity studies of pyrethroids:19. The rate of development of the knockdown symptom in house flies (II)

Authors
Journal
Pesticide Biochemistry and Physiology
0048-3575
Publisher
Elsevier
Publication Date
Volume
35
Issue
3
Identifiers
DOI: 10.1016/0048-3575(89)90088-6
Disciplines
  • Chemistry

Abstract

Abstract The intrinsic knockdown activity of various chrysanthemic and pyrethric acid esters and related compounds was evaluated in terms of the dose required to cause the knockdown symptom in certain fractions of a test insect population from the “time-independent” dose-response relationships under synergistic conditions. The rate constant of development of the knockdown symptom was estimated from the intrinsic knockdown activity and the activity at the earliest stages of intoxication according to first-order kinetics with a two-compartment model. Variations in the rate constant were analyzed quantitatively with physicochemical molecular parameters and regression analysis. The most important parameter in governing the rate constant was the hydrophobicity (log P) of the molecule, the optimum value being about 5.5.

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