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Prostacyclin and prostagladin synthesis in isolated brain capillaries

Authors
Journal
Prostaglandins & Other Lipid Mediators
0090-6980
Publisher
Elsevier
Publication Date
Volume
23
Issue
3
Identifiers
DOI: 10.1016/0090-6980(82)90074-0

Abstract

Abstract The synthesis of prostacyclin and prostaglandins was examined in isolated blood-free brain capillaries of guinea-pigs and rats using 1- 14C-arachidonic acid as a precursor. The main prostaglandins synthesized by guinea-pig microvessels were prostaglandin D 2 and prostaglandin E 2. Substantially less prostaglandin F 2 α or the prostacyclin stable metabolite, 6-oxo-prostaglandin F 1 α was synthesized. Rat capillary prostaglandin distribution differed substantially from that of the guinea-pigs although the principle prostaglandin was also PGD 2. Total prostaglandin conversion was greater in guinea-pig capillaries than in the rat. Norepinephrine stimulated the prostaglandin forming capacity of blood free cerebral microvasculature of guinea-pigs. Prostacyclin and prostaglandins could be involved in the activity dependent regulation of regional cerebral blood flow and permeability.

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