Affordable Access

Publisher Website

Preserve and protect: maintaining axons within functional circuits

Authors
Journal
Trends in Neurosciences
0166-2236
Publisher
Elsevier
Identifiers
DOI: 10.1016/j.tins.2014.07.007
Keywords
  • Axon Injury
  • Axon Maintenance
  • Axon Survival
  • Neurodegeneration
  • Neurotrophins
  • Wallerian Degeneration
Disciplines
  • Biology
  • Medicine

Abstract

During development, neural circuits are initially generated by exuberant innervation and are rapidly refined by selective preservation and elimination of axons. The establishment and maintenance of functional circuits therefore requires coordination of axon survival and degeneration pathways. Both developing and mature circuits rely on interdependent mitochondrial and cytoskeletal components to maintain axonal health and homeostasis; injury or diseases that impinge on these components frequently cause pathologic axon loss. Here, we review recent findings that identify mechanisms of axonal preservation in the contexts of development, injury, and disease.

There are no comments yet on this publication. Be the first to share your thoughts.