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Evaluation of an experimental system for thein vitroassessment of ultrasonic contrast agents

Authors
Journal
Ultrasound in Medicine & Biology
0301-5629
Publisher
Elsevier
Publication Date
Volume
26
Issue
1
Identifiers
DOI: 10.1016/s0301-5629(99)00104-0
Keywords
  • Ultrasound
  • Contrast Agent
  • Normalised Backscatter
  • Degassing
  • Rf Data Acquisition
  • Blood-Mimicking Fluid
  • Grey-Scale Phantom
  • Myomap™
  • Dmp115
Disciplines
  • Chemistry

Abstract

Abstract The ultrasonic properties of microbubble contrast agents need to be fully understood if reproducible images and quantitative results are to be produced. Additional aspects of the physical and chemical environment into which the contrast agents are introduced also need to be taken into account, and their effect on contrast agent performance evaluated. A setup that provides an accurate and reproducible data-acquisition system is presented and evaluated in this paper. The linear range of this system is assessed, as well as its accuracy and precision. A new approach to the investigation of contrast agents, based on normalised backscatter, is discussed. Also, a common technique of degassing, widely used in other areas, is described and evaluated to determine its appropriateness to contrast agent studies.

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