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Mechanisms of the vascular effect of pressor hormones

Authors
Publisher
Elsevier Inc.
Publication Date
Volume
62
Issue
11
Identifiers
DOI: 10.1016/0002-9149(88)90032-x
Disciplines
  • Biology
  • Medicine

Abstract

Abstract There exists a considerable gap between the recognition of the effects of pressor hormones and the understanding of their mechanisms. Studies are necessary to provide a more accurate basis for potential therapeutic interventions on the hormonal mechanisms of hyper- and hypotensive states. From recent and previous experimental results, a modified model of vascular smooth muscle cell activation is emerging. In this model, contraction is a complex process involving Ca 2+ release, protein kinase C and ionic channel activation and modification in pH and energy metabolism. The combined action of these processes is necessary for the full expression of the contractile response.

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