Affordable Access

Publisher Website

Association of three polymorphisms inARID5B,IKZF1andCEBPEwith the risk of childhood acute lymphoblastic leukemia in a Chinese population

Authors
Journal
Gene
0378-1119
Publisher
Elsevier
Publication Date
Volume
524
Issue
2
Identifiers
DOI: 10.1016/j.gene.2013.04.028
Keywords
  • Polymorphisms
  • Arid5B
  • Childhood Acute Lymphoblastic Leukemia
  • Susceptibility

Abstract

Abstract Recent genome-wide association studies (GWAS) that focus on childhood acute lymphoblastic leukemia (ALL), the most common malignancy in children younger than 15years old, have found evidence that single nucleotide polymorphisms (SNPs) in IKZF1 (7p12.2), ARID5B (10q21.2) and CEBPE (14q11.2) are strongly related to the risk of childhood ALL. These polymorphisms may lead to abnormal expression and dysfunction of the corresponding transcription factors and are likely to increase the risk of ALL. To validate the relationship between these SNPs and the risk of childhood ALL in Chinese population, we conducted a case–control study of 570 ALL cases and 673 controls. We determined that the SNP rs10821936 in ARID5B was statistically significantly associated with the risk of childhood ALL (P<0.0001). The results were also significant for the subgroup analysis of high-risk, medium-risk and low-risk ALL as well as B-lineage ALL. Statistically significant differences were not found in the SNPs for IKZF1 and CEBPE. In conclusion, ARID5B rs10821936 could serve as a potential biomarker for assessing the risk of childhood ALL in Chinese children.

There are no comments yet on this publication. Be the first to share your thoughts.