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Functional divergence of gene duplicates through ectopic recombination

Authors
Journal
EMBO Reports
1469-221X
Publisher
EMBO
Publication Date
Volume
13
Issue
12
Identifiers
DOI: 10.1038/embor.2012.157
Keywords
  • Scientific Reports

Abstract

Gene duplication stimulates evolutionary innovation as the resulting paralogs acquire mutations that lead to sub- or neofunctionalization. A comprehensive in silico analysis of paralogs in Saccharomyces cerevisiae reveals that duplicates of cell-surface and subtelomeric genes also undergo ectopic recombination, which leads to new chimaeric alleles. Mimicking such intergenic recombination events in the FLO (flocculation) family of cell-surface genes shows that chimaeric FLO alleles confer different adhesion phenotypes than the parental genes. Our results indicate that intergenic recombination between paralogs can generate a large set of new alleles, thereby providing the raw material for evolutionary adaptation and innovation.

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