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Kindling-like stimulus patterns induce epileptiform discharges in the guinea pig in vitro hippocampus

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
60
Issue
1
Identifiers
DOI: 10.1016/0304-3940(85)90376-3
Keywords
  • Hippocampus
  • Long-Term Potentiation
  • Kindling
  • Epilepsy
  • N-Methyl-D-Aspartate Receptor
  • Guinea Pig

Abstract

Abstract In the guinea pig in vitro hippocampal slice preparation, we have demonstrated that the repeated tetanic stimulation of the Schaffer collateral-commissural input to CA1 pyramidal neurones produces a progressive increase in the amplitude and duration of postsynaptic potentials, and stimulus-induced and spontaneous paroxysmal depolarization shifts (PDSs). Both the enhancement of synaptic transmission and the genesis of PDSs were reversibly blocked by the N-methyl- d-aspartate (NMDA) receptor antagonist (±)-2-amino-5-phosphonovalerate (APV). These results provide evidence that progressive, stimulation-induced long-term potentiation may serve as the trigger for kindling-induced epileptogenesis, and this process is dependent on the repeated activation of an APV-sensitive receptor.

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