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The mouseBrachyury (T)gene

Authors
Publisher
Elsevier Inc.
Publication Date
Volume
6
Issue
6
Identifiers
DOI: 10.1016/s1044-5781(06)80002-2
Keywords
  • Brachyury
  • Embryogenesis
  • Mesoderm
  • Mouse
  • Notochord

Abstract

The isolation of the mouse Brachyury (T) gene has provided an important molecular tool for the investigation of mesoderm formation and axial development in vertebrates. The T gene is expressed specifically in nascent and early migrating mesoendoderm, and in notochord cells. It acts as a transcription factor controlling the differentiation of notochord cells, and the formation of mesoderm in the posterior of the embryo. Thus, mouse embryos lacking T function cannot undergo trunk nor tail formation. T plays distinct roles in the two cell types.

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