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Methinks it is like a folding curve

Authors
Journal
Biophysical Chemistry
0301-4622
Publisher
Elsevier
Publication Date
Identifiers
DOI: 10.1016/s0301-4622(02)00147-3
Keywords
  • Protein Folding
  • Conformational Entropy
  • Random Coil
Disciplines
  • Biology

Abstract

Abstract Most often, the unfolded state of peptides and proteins has been modeled as a statistical random coil. Here, we suggest an alternative model based on the presence of a significant, temperature-dependent conformational bias in the unfolded population. Conformational bias is suggested by our calculations [Proc. Natl. Acad. Sci. USA 96 (1999) 14258–14263], and it is found in recent studies of both proteins and peptides. The imposition of even a modest bias would transform our assessment of the folding problem.

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