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Cross-Aldol condensation of isobutyraldehyde and formaldehyde using phase transfer catalyst

Authors
Publisher
Elsevier B.V.
Identifiers
DOI: 10.1016/j.jscs.2012.12.012
Keywords
  • Hydroxypivaldehyde
  • Neopentyl Glycol
  • Benzyltrimethylammonium Hydroxide

Abstract

Abstract The hydroxypivaldehyde (HPA) precursor intermediate for the synthesis of neopentyl glycol (NPG) is prepared by novel cross Aldol condensation of isobutyraldehyde and formaldehyde at 20°C using benzyltrimethylammonium hydroxide, a basic phase transfer catalyst. A feed mole ratio of 1.1:1.0:0.04 (isobutyraldehyde:formaldehyde:benzyltrimethylammonium hydroxide) afforded hydroxypivaldehyde as white solid in almost quantitative yield with ∼100% selectivity.

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