Affordable Access

Publisher Website

Genotoxicity to Human Cells Induced by Air Particulates Isolated during the Kuwait Oil Fires

Authors
Journal
Environmental Research
0013-9351
Publisher
Elsevier
Publication Date
Volume
64
Issue
1
Identifiers
DOI: 10.1006/enrs.1994.1003

Abstract

Abstract In an effort to examine the potential of exposure to soot from the 1991 oil fires in the Kuwait desert for inducing genetic effects we studied the in vitro genotoxicity of this material. Air particulates isolated near the Kuwait oil fires were studied using three assays. Dose-dependent increases were observed for both sister chromatid exchanges in human peripheral blood lymphocytes and mutation at the hprt locus in the metabolically competent human lymphoblast cell line AHH-l. Similar magnitudes of response were seen using these two assays when testing a standard air particulate sample which had been isolated from the Washington, DC, area. Using the 32P-postlabeling assay, no increase in DNA adduct formation was observed in AHH-l cells treated with particulates isolated from sampling in Kuwait.

There are no comments yet on this publication. Be the first to share your thoughts.