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ALS Model Glia Can Mediate Toxicity to Motor Neurons Derived from Human Embryonic Stem Cells

Authors
Journal
Cell Stem Cell
1934-5909
Publisher
Elsevier
Publication Date
Volume
3
Issue
6
Identifiers
DOI: 10.1016/j.stem.2008.11.004

Abstract

In this issue of Cell Stem Cell, Di Giorgio et al. (2008) and Marchetto et al. (2008) culture motor neurons derived from human embryonic stem cells with astrocytes expressing mutant SOD1. In these human ALS models, motor neurons are selectively destroyed by mutant astrocyte-secreted factors, and potential neuroprotective pathways are revealed.

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