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Elevated expression of neurotrophin-3 mRNA in sensory nerve of streptozotocin-diabetic rats.

Neuroscience Letters
Publication Date
  • Animals
  • Metabolism: Blood Glucose
  • Genetics: Diabetes Mellitus
  • Experimental
  • Gene Expression Regulation
  • Male
  • Genetics: Nerve Growth Factors
  • Metabolism: Neurons
  • Afferent
  • Neurotrophin 3
  • Genetics: Rna
  • Messenger
  • Rats
  • Rats
  • Wistar
  • Reference Values
  • Reverse Transcriptase Polymerase Chain Reaction
  • Metabolism: Sciatic Nerve
  • Metabolism: Skin
  • Support
  • Non-U.S. Gov'T
  • Metabolism: Sural Nerve
  • Transcription
  • Genetic
  • Medicine


Decreased expression of NT-3 mRNA in the sciatic nerve and leg muscles of streptozotocin (STZ)-diabetic rats has been associated with the pathogenesis of diabetic neuropathy. The aim of this study was to determine whether STZ-induced diabetes also affects the expression of NT-3 mRNA in the central and peripheral projections of sensory nerves. Competitive reverse transcription-polymerase chain reaction (cRT-PCR) was used to quantify the levels of NT-3 mRNA in the dorsal root, sural nerve, sciatic nerve and foot skin of age-matched and 12-week STZ-diabetic rats. Diabetes increased by 52% (P < 0.05) the expression of NT-3 mRNA in the dorsal root and sural nerve. It is proposed that diabetes-induced sensory nerve damage may elevate NT-3 mRNA production which may act as a source of neurotrophic support for sensory axons whose target-derived supply of NT-3 may be impaired.

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