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31P-NMR studies of glucose and glutamine metabolism in cultured mammalian cells.

Authors
  • Sri-Pathmanathan, R M
  • Braddock, P
  • Brindle, K M
Type
Published Article
Journal
Biochimica et Biophysica Acta
Publisher
Elsevier
Publication Date
Feb 19, 1990
Volume
1051
Issue
2
Pages
131–137
Identifiers
PMID: 2310767
Source
Medline
License
Unknown

Abstract

31P-NMR measurements of the concentrations of phosphorus-containing metabolites in mammalian cells immobilised and perifused with glucose and glutamine as sole carbon source have shown that the intracellular Pi concentration is significantly higher in cells perifused with glutamine than with glucose. The data are consistent with the proposal that the rate of glutamine utilisation may be controlled by the activity of phosphate-activated glutaminase.

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