Thrombosis is a rare cause of superior vena cava (SVC) syndrome. We report a 37-year-old man hospitalized because of swelling of the face and neck. A computed tomography angiography showed a thrombotic obstruction of SVC. The patient was treated by percutaneous transluminal balloon angioplasty of the SVC and placement of a stent. The symptoms disappeared, but the patient was hospitalized again after 3 months for the same complaints. Computed tomography angiography showed thrombosis in the stent in the SVC. The SVC was replaced with a prosthetic blood vessel. The patient's postoperative recovery was uneventful, and SVC syndrome did not occur during 2 years of postoperative follow-up.