Affordable Access

Publisher Website

Placental passage of angiotensin-converting enzyme inhibitors

Authors
Journal
American Journal of Obstetrics and Gynecology
0002-9378
Publisher
Elsevier
Publication Date
Volume
174
Issue
5
Identifiers
DOI: 10.1016/s0002-9378(96)70587-2
Keywords
  • Angiotensin-Converting Enzyme Inhibitors
  • Fetopathy
  • Placental Passage
  • Perfusion Model
Disciplines
  • Biology
  • Pharmacology

Abstract

Abstract OBJECTIVE: Placental passage of the angiotensin-converting enzyme inhibitors temocapril and enalapril was investigated in a placental perfusion model. STUDY DESIGN: In an open system a placental lobe was perfused on both the maternal and the fetal side with a blood-free medium containing the test substances plus a reference substance on the maternal side. Six placentas were perfused with temocapril and five with enalapril. The drugs were measured by gas chromatography – mass spectrometry. RESULTS: Both angiotensin-converting enzyme inhibitors crossed the human placenta in the maternal-fetal direction in similar quantities. Temocapril showed the same pharmacokinetic characteristics as enalapril. CONCLUSIONS: This was the first study to quantify the placental transfer of angiotensin-converting enzyme inhibitors. These antihypertensive agents should not be taken during pregnancy, to avoid any potential hazards to the fetus. (A M J O BSTET G YNECOL 1996;174:1450-5.)

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Placental passage of angiotensin-converting enzyme...

on American Journal of Obstetrics... May 1996

Angiotensin converting enzyme inhibitors and cough...

on Journal of Cardiovascular Phar... 1989

Angiotensin converting enzyme inhibitors.

on Journal of hypertension November 1991

[Angiotensin converting enzyme inhibitors].

on Nihon rinsho. Japanese journal... February 2000
More articles like this..