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Charlotte auerbach and chemical mutagenesis

Authors
Journal
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
0027-5107
Publisher
Elsevier
Publication Date
Volume
29
Issue
2
Identifiers
DOI: 10.1016/0027-5107(75)90111-6
Disciplines
  • Chemistry

Abstract

Abstract A review is presented of the many conceptual contributions of Charlotte Auerbach to the development of the field of chemical mutagenesis during the past thirty years. The following aspects are discussed: (1) differences between the genetic effects of chemicals and X-rays; (2) mosaicism, delayed mutation and replicating instabilities; (3) mutation as a cellular process; (4) specificity; (5) dose-effect curves, and (6) correlation between different kinds of damage.

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