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Chemical Ligation—An Unusual Paradigm in Protease Inhibition

Authors
Journal
Molecular Cell
1097-2765
Publisher
Elsevier
Publication Date
Volume
21
Issue
6
Identifiers
DOI: 10.1016/j.molcel.2006.03.001
Disciplines
  • Biology

Abstract

Some protease inhibitors use uncommon mechanisms to restrain the activity of their target enzymes. A recent paper in Chemistry and Biology ( Lu et al., 2006) demonstrates a curious mechanism of inhibition of a caspase, relying on principles of native peptide ligation.

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