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Regional distribution of high-affinity L-tryptophan uptake in rat brain

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
8
Issue
1
Identifiers
DOI: 10.1016/0304-3940(78)90099-x

Abstract

Abstract L-tryptophan is accumulated by slices of seven regions of the rat brain in a saturable, energy-depending fashion, with K m-values ranging from 53 to 142 μM. The maximal number of L-tryptophan accumulating sites differs only by about two-fold for the brain regions investigated. The regional distribution of the high-affinity L-tryptophan uptake does not correlate with the amount of serotonin synaptosomal uptake and apparent receptor binding. It is assumed that a specific role of the L-tryptophan uptake system within the serotoninergic system in the brain is questionable.

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