Affordable Access

Publisher Website

Histamine turnover in regions of rat brain

Brain Research
Publication Date
DOI: 10.1016/0006-8993(84)90655-3
  • Histamine
  • Parygline
  • Monoamine Oxidase
  • Turnover
  • Brain


Abstract Rapid and complete inhibition of monoamine oxidase by pargyline produced linear increases in the content of the histamine metabolite, tele-methylhistamine (t-MH), in 9 regions of rat brain 2 and 4 h after drug administration. The treatment had little or no effect on the histamine content of these regions. As histamine methylation is the major metabolic pathway of histamine in brain, the rate of increase in brain t-MH content after complete inhibition of its metabolism provides an estimate of histamine turnover. Histamine turnover rates varied over 46-fold among regions, from cerebellum (0.029 nmol/g·h) to hypothalamus (1.33 nmolη), similar to those reported for norepinephrine and serotonin. Turnover rates were highly correlated with control t-MH levels ( r = 0.97) and control histamine levels ( r = 0.84). Rate constants were highest in the caudate nucleus and frontal cortex, equivalent to a half-life of about 11 min in these regions. While hypothalamic histamine had the highest turnover rate, the rate constant for histamine in this region was among the lowest in brain, perhaps consistent with the presence of histaminergic cell bodies. Histamine turnover rates may be indicative of the activity of histamine-synthesizing neurons, and their determination will facilitate understanding of histamine in brain.

There are no comments yet on this publication. Be the first to share your thoughts.


Seen <100 times

More articles like this

Histamine turnover in regions of rat brain.

on Brain Research Jan 16, 1984

Histamine turnover in rat brain

on Brain Research Jan 01, 1974

Polyamine turnover in different regions of rat bra...

on Journal of Neurochemistry May 1973

Barbiturate-induced inhibition of rat brain histam...

on Biochemical Pharmacology Oct 01, 1987
More articles like this..