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Fluorinated nucleosides: Synthesis and biological implication

Authors
Journal
Journal of Fluorine Chemistry
0022-1139
Publisher
Elsevier
Publication Date
Volume
129
Issue
9
Identifiers
DOI: 10.1016/j.jfluchem.2008.06.007
Keywords
  • Fluorinated Nucleosides
  • Antiviral Activity
  • Anti-Cancer Activity
Disciplines
  • Biology
  • Pharmacology

Abstract

Abstract A number of important pharmaceuticals have been discovered and developed based on fluorinated analogs of biologically active nucleosides. The introduction of fluorine into a nucleoside structure at an appropriate position has modulated and/or improved the pharmacological properties of a molecule. The present review deals with the synthetic methodology, structural and biological implication of carbohydrate-modified fluoronucleosides.

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